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in a way that cannot be regained or recovered
- The computer crashed, and the data was irretrievably lost despite attempts to recover it.
- The trust between them was irretrievably broken after the betrayal.
- The ancient artifact was mishandled and irretrievably damaged during excavation.
- The relationship soured irretrievably due to ongoing misunderstandings.
- The confidential information was leaked, leading to irretrievably damaged reputations.