Irritation

used to show affection or add humor when addressing a person

We went to the most incredible concert last night, and the lead singer, that son of a gun, blew us away.

to no longer have the tolerance to endure more of something

I have had enough of his constant complaining; it's time for him to find some solutions.

very annoyed with a situation that has gone on for an extended period of time

I'm sick to the back teeth with his constant excuses for not completing his work on time.

used to describe someone who is very unpleasant or bad-tempered

After the argument, his mood became as sour as vinegar, and he refused to speak to anyone.

to constantly annoy someone and ruin their concentration

The constant interruptions and noise in the office drive me to distraction; I can't concentrate on my work.

a thoroughly mean, despicable, or disagreeable person

They are frustrated with that son of a bitch neighbor who never respects their privacy.