sickle-cell disease
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镰状细胞病, 镰状细胞贫血
a genetic blood disorder where red blood cells assume an abnormal, crescent shape, leading to various complications
Sickle-cell disease is a genetic blood disorder that affects the shape and function of red blood cells. Normally, red blood cells are round and flexible, allowing them to move easily through blood vessels. In sickle-cell disease, the red blood cells become stiff and curved like a crescent or sickle. These misshapen cells can block blood flow, leading to pain, infections, and organ damage. Symptoms of sickle-cell disease include episodes of severe pain, fatigue, swelling in the hands and feet, frequent infections, and delayed growth in children. Treatment for sickle-cell disease focuses on managing symptoms and preventing complications and may include medications, blood transfusions, and in some cases, a bone marrow transplant.
- Sickle cell disease results from a mutation in the HBB gene.
镰状细胞病是由HBB基因突变引起的。
- Symptoms of sickle cell disease include pain episodes, anemia, and etc.
镰状细胞病的症状包括疼痛发作、贫血等。
- Supportive care is essential for individuals with sickle cell disease.
对于患有镰状细胞病的个体来说，支持性护理至关重要。
- Public health efforts focus on improving access to comprehensive care for individuals with sickle cell disease.
公共卫生工作重点在于改善镰状细胞病患者获得全面护理的机会。
- Sickle cell disease is more prevalent in individuals of African, Mediterranean, and Middle Eastern descent.
镰状细胞病在非洲、地中海和中东血统的个体中更为普遍。